#Icad medical stroke trial#

'This clinical trial moves us significantly closer to preventing strokes and death in high-risk populations,' said Keith Black, MD, professor and chair of the Department of Neurosurgery.

While this Phase IIa trial selected patients from previous studies as the control group, the Phase III study would enroll new ICAD patients for both the control and experimental groups, he explained. Gonzalez said his team is working with the stroke prevention working group of the National Institutes of Health to develop a proposal for a Phase III randomized clinical trial across multiple institutions to further test the effectiveness of EDAS as compared with intensive medical management. Despite advances in medical care, annual rates of recurrent stroke and death are remain high, at 15 percent or more for ICAD patients, according to published research. 'Developing new therapeutic strategies is crucial for ICAD patients.'Д¬urrent ICAD therapies-in addition to intensive medical management-include bypass surgery to connect a blood vessel from outside the brain to a vessel inside the brain, as well as angioplasty with stenting, which involves inflating a tiny balloon inside a cerebral artery to open it up and placing a stent device inside the artery. 'Even under the best current treatments, ICAD carries high rates of recurrent stroke and death, compared with other causes of stroke,' he said. Gonzalez said the new trial addressed a serious medical need. Previously, EDAS has been used for moyamoya disease, a rare cerebrovascular disorder that affects younger patients. 'Our findings in this intermediate-stage trial are promising for applying EDAS surgery to intracranial atherosclerotic disease,' said Gonzalez said. Two of the EDAS patients had small wound openings that required additional surgical interventions, but there were no intracranial hemorrhages or other serious adverse events, the researchers reported. These patients received EDAS surgery, along with intensive medical management, which included diet and lifestyle changes, blood thinners and other medications to control blood pressure, cholesterol and blood sugar levels.ДЄfter one year, 9.6 percent of the patients treated with the surgery experienced another ischemic stroke or died, compared with 21.2 percent of patients in a matched control group who received only intensive medical management. Gonzalez, MD, professor of Neurosurgery and director of the Neurovascular Laboratory at Cedars-Sinai, enrolled 52 patients with severe brain atherosclerosis, also known as intracranial atherosclerotic disease, or ICAD, who showed symptoms of either a recent stroke or a mini-stroke, called a transient ischemic attack. Over time, new blood vessels form, creating fresh pathways for blood and oxygen to reach the brain. Neurosurgeons performing EDAS reroute arteries from the scalp and the membranes that cover the brain and place these arteries under the skull near areas of the brain at risk of stroke. Atherosclerotic disease, in which plaque buildup narrows the brain arteries, is one of the most common causes of strokes. 18, 2018 10:05AM ET) - A surgical technique called EDAS (encephaloduroarteriosynangiosis) significantly decreases the rate of stroke recurrence and death for patients with severe atherosclerosis of the brain arteries, according to findings of a Phase IIa clinical trial presented today at the World Stroke Congress in Montreal.

Panel D displays an angiogram of a patient's brain six months after the surgery, showing the new paths created (white arrows). Over time, branches grow from the artery, providing new pathways for brain circulation (Panel C). They put the bone flap back in place (Panel B). Image:В In the EDAS (encephaloduroarteriosynangiosis) operation, surgeons reroute a scalp artery and place it near the surface of the brain in need of additional blood flow (Panel A).